SubQ Testosterone for Women: Strength and Balance
Abstract
Testosterone is often associated with men, but women naturally produce this hormone throughout life. In women, testosterone contributes to sexual function and interacts with muscle, bone, metabolism, and other body systems. When testosterone therapy is clinically appropriate, treatment should be individualized and monitored so hormone levels remain within the normal female physiologic range. Subcutaneous testosterone injections place a small amount of medication into fatty tissue just beneath the skin, where it is gradually absorbed. However, the strongest clinical evidence for testosterone therapy in women remains with transdermal treatment, especially for postmenopausal women with hypoactive sexual desire disorder, or HSDD.
At ChiroMed – Integrated Medicine in El Paso, Texas, this topic fits within a broader model of coordinated healthcare. Chiropractic care, nurse practitioner services, rehabilitation, nutrition, functional health strategies, and medical oversight can work together to address a patient’s musculoskeletal function and overall health rather than focusing on hormone levels alone. ChiroMed describes its approach as bringing multiple healthcare disciplines together to create individualized, patient-centered treatment plans.

Understanding Testosterone in Women
Testosterone is a natural part of female physiology. The ovaries and adrenal glands contribute to androgen production, and testosterone levels normally change with age. Levels can also fall more quickly after ovary removal.
Testosterone interacts with many tissues throughout the body, including the brain, muscles, bones, reproductive tissues, and blood-forming system. However, recognizing these biological roles does not mean testosterone therapy has been proven to treat every symptom that may occur during menopause.
The strongest evidence currently supports systemic testosterone therapy for appropriately evaluated postmenopausal women with HSDD. HSDD involves persistent loss of sexual desire that causes personal distress. Major international organizations have concluded that this is the clearest evidence-supported indication for testosterone therapy in women (Davis et al., 2019).
A large systematic review and meta-analysis also found that testosterone can improve several areas of sexual function in postmenopausal women, including sexual desire, arousal, pleasure, orgasm, responsiveness, and sexual self-image (Islam et al., 2019).
That distinction matters. Testosterone should not simply be prescribed because a laboratory value appears low.
What Are Subcutaneous Testosterone Injections?
A subcutaneous, or SubQ, injection places medication into fatty tissue beneath the skin rather than deeply into a muscle.
Testosterone cypionate may be prepared in concentrations that allow very small doses to be administered. Once placed into subcutaneous tissue, the medication forms a depot from which testosterone is gradually absorbed.
For women, the treatment goal is very different from testosterone treatment designed to produce male hormone concentrations. When testosterone is used for female HSDD, expert guidance recommends keeping concentrations within the physiologic range normally seen in premenopausal women rather than pushing testosterone above that range (Parish et al., 2021).
The attached clinical white paper makes an important distinction about SubQ injections. Randomized efficacy evidence in women is strongest for transdermal patches, creams, and gels. It describes subcutaneous injection as a titratable route with physiologic reasoning behind it, but notes that there is no dedicated randomized efficacy trial establishing SubQ testosterone injections for women.
That means SubQ testosterone should not be described as better proven than transdermal therapy. It is an alternative route that requires careful medical prescribing, laboratory monitoring, informed consent, and follow-up.
A “Low Testosterone” Number Is Not the Diagnosis
Laboratory testing is useful, but testosterone therapy in women should not begin solely because one test result falls near the lower end of a reference range.
The ISSWSH clinical guideline recommends a biopsychosocial assessment before treatment. A clinician may need to consider menopause status, medications, relationship factors, depression or anxiety, sleep, vaginal discomfort, pain during intercourse, medical illnesses, and other issues that can affect sexual desire. Total testosterone is useful mainly as a baseline and monitoring measurement rather than as a diagnostic test for HSDD (Parish et al., 2021).
The clinical white paper emphasizes the same principle. Testosterone measurements become especially important after therapy begins, because they help the healthcare team determine whether treatment remains within a physiologic female range and whether the patient is receiving too much hormone.
Testosterone, Muscle, and Musculoskeletal Health
Testosterone interacts with skeletal muscle biology, which is one reason the hormone receives attention in discussions about aging, physical function, and strength.
A randomized study examined different testosterone doses in postmenopausal women who had undergone hysterectomy. Higher testosterone concentrations were associated with changes in lean body mass and some measurements of muscle power. Importantly, the clearer muscle effects occurred with the highest dose and testosterone concentrations above typical female physiologic levels. The authors also stated that longer-term trials were needed to balance potential benefits against long-term risks (Huang et al., 2014).
This research should not be interpreted to mean that testosterone is a proven muscle-building treatment for women. The clinical white paper specifically notes that body-composition benefits have not been established as an approved indication for female testosterone therapy.
This is where physical rehabilitation becomes important. Hormones may influence the environment in which muscle tissue functions, but stronger muscles still require appropriate loading, movement, nutrition, recovery, and neuromuscular training.
Connecting Testosterone Therapy With Chiropractic Care
Chiropractic treatment and testosterone therapy perform very different jobs.
Testosterone therapy is a medical treatment that requires appropriate prescribing and monitoring. Chiropractic care focuses on the musculoskeletal system, including joint movement, spinal mechanics, posture, physical function, and rehabilitation.
For a woman who is also trying to maintain strength and mobility as she ages, an integrated plan may include:
- medically supervised hormone assessment when clinically indicated;
- chiropractic evaluation of the spine, pelvis, and extremities;
- resistance and strength rehabilitation;
- balance, mobility, and stability exercises;
- adequate dietary protein and overall nutrition;
- evaluation of sleep and recovery;
- management of previous injuries or chronic musculoskeletal limitations;
- progressive exercise based on the patient’s current ability;
- laboratory monitoring when hormone therapy is prescribed;
- ongoing reassessment of both symptoms and physical function.
The important idea is that testosterone does not replace exercise or rehabilitation. Likewise, an adjustment cannot correct a hormone disorder. When appropriate, the two approaches can address different parts of the patient’s health.
How This Fits the ChiroMed Integrated Medicine Model
ChiroMed – Integrated Medicine in El Paso brings several healthcare services into a multidisciplinary setting. The clinic currently describes chiropractic care, nurse practitioner services, rehabilitation, nutrition, acupuncture, and related integrative services as parts of its overall healthcare model.
That structure can be useful when women’s hormone concerns overlap with other health issues.
For example, a woman discussing hormonal symptoms may also have chronic back pain, reduced physical activity, previous injury, poor sleep, loss of conditioning, weight concerns, or difficulty maintaining muscle strength. Treating only a laboratory number would not address all of those factors.
ChiroMed’s integrated injury model similarly describes combining medical evaluation, chiropractic care, rehabilitation, soft-tissue treatment, and functional medicine strategies within a coordinated recovery plan.
Dr. Alexander Jimenez, DC, APRN, FNP-BC, works within this multidisciplinary environment by integrating chiropractic and musculoskeletal assessment with his advanced-practice nursing and functional medicine background. His clinical approach emphasizes movement, nutrition, metabolic health, rehabilitation, and other factors that affect how a patient feels and functions.
Medical oversight is also part of the ChiroMed structure. ChiroMed identifies Maria Guadalupe Cardenas, MD, a board-certified internal medicine physician, as Medical Director, Clinical Director, and Collaborative Physician. The ChiroMed website lists her Texas medical license as J2933 and NPI as 1164426748.
In a multidisciplinary model, the goal is not to make chiropractic treatment a substitute for medical hormone management. Instead, medical and musculoskeletal professionals can contribute within their respective scopes of practice.
Monitoring Testosterone Therapy in Women
If testosterone treatment is selected, follow-up is an essential part of care.
The clinical guideline recommends monitoring testosterone concentrations to prevent exposure above the physiologic premenopausal range. Patients should also be evaluated for clinical signs of androgen excess (Parish et al., 2021).
Possible concerns can include acne, increased facial or body hair, scalp hair changes, and other androgenic effects. Voice changes are less common but deserve prompt attention. The attached white paper explains that these effects tend to be dose-related and that scheduled reassessment helps identify excessive exposure early.
A clinician may also consider the patient’s overall medical history, cardiovascular health, breast health, medications, and other hormone therapy.
Importantly, testosterone should not simply be increased because symptoms have not changed quickly. Expert guidance suggests evaluating response over several months and stopping treatment when there is no meaningful benefit rather than pushing testosterone beyond the normal female physiologic range.
What We Still Do Not Know
Testosterone therapy in women is an area where evidence and clinical practice do not always move at the same speed.
Transdermal testosterone has the strongest randomized evidence. The evidence supporting subcutaneous injections in women remains much more limited. The attached white paper specifically identifies subcutaneous injection evidence as pharmacokinetic rather than supported by dedicated female efficacy trials.
Long-term cardiovascular and breast safety also remain incompletely defined. Available shorter-term findings at physiologic doses are reassuring, but researchers still lack adequately powered studies that answer every safety question over many years.
This is why individualized treatment and shared decision-making matter.
Integrating Hormone Health With Movement and Strength
Women’s health is rarely about one hormone, one joint, or one treatment.
For selected women with HSDD, properly monitored testosterone therapy may be one part of care. If a SubQ route is considered, the treatment should remain medically supervised and should recognize that evidence for female subcutaneous injections is still developing.
At the same time, maintaining musculoskeletal health requires movement.
Progressive resistance exercise, adequate nutrition, good sleep, rehabilitation, healthy body composition, joint mobility, and injury management all contribute to maintaining strength and physical independence.
That concept fits naturally with the ChiroMed – Integrated Medicine approach in El Paso: combining conventional medical oversight with chiropractic care, rehabilitation, nutrition, functional strategies, and individualized patient education. ChiroMed describes its purpose as bringing different disciplines together so treatment plans can address both symptoms and underlying contributors to health and function.
Testosterone therapy and chiropractic care should therefore not be viewed as competing treatments. When clinically appropriate, each addresses different parts of the larger goal—helping women maintain healthy physiology, functional muscles and joints, mobility, and quality of life.
References
Davis, S. R., Baber, R., Panay, N., et al. (2019). Global consensus position statement on the use of testosterone therapy for women. Journal of Clinical Endocrinology & Metabolism, 104(10), 4660-4666.
Hatzilabrou, T. A. (n.d.). Testosterone therapy in women. Worldborne Medical, Clinical Frontiers: Androgens Series.
Huang, G., Basaria, S., Travison, T. G., et al. (2014). Testosterone dose-response relationships in hysterectomized women with or without oophorectomy: Effects on sexual function, body composition, muscle performance and physical function in a randomized trial. Menopause, 21(6), 612-623.
Islam, R. M., Bell, R. J., Green, S., Page, M. J., & Davis, S. R. (2019). Safety and efficacy of testosterone for women: A systematic review and meta-analysis of randomised controlled trial data. The Lancet Diabetes & Endocrinology, 7(10), 754-766.
Parish, S. J., Simon, J. A., Davis, S. R., et al. (2021). International Society for the Study of Women’s Sexual Health clinical practice guideline for the use of systemic testosterone for hypoactive sexual desire disorder in women. The Journal of Sexual Medicine, 18(5), 849-867.
ChiroMed – Integrated Medicine. (2026). ChiroMed – Integrated Medicine: Holistic healthcare in El Paso, Texas.
ChiroMed – Integrated Medicine. (2026). Integrated medicine services in El Paso, Texas.








